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[Arabidopsis] Postdoc opportunity at the University of Edinburgh with Steven Spoel

Geraint Parry via arab-gen%40net.bio.net (by geraint from garnetcommunity.org.uk)
Wed May 17 08:14:41 EST 2017

Postdoc in Ubiquitin-Mediated Gene Expression

A Postdoctoral Research Assistant position is available in the
laboratory of Dr. Steven Spoel at the School of Biological Sciences,
University of Edinburgh. You will join an active research programme
funded by the European Research Council (ERC) that is aimed at
elucidating the mechanisms of gene regulation during plant immune

Activation of plant immunity is associated with dramatic reprogramming
of the transcriptome to prioritise development of immunity over normal
cellular growth functions. Transcription reprogramming is largely
orchestrated by the immune hormone, salicylic acid (SA), which
accumulates upon infection and establishes both local and broad-spectrum
systemic immunity. We previously reported that perception of SA is
mediated by ubiquitin ligases that alter the stability of an
indispensable transcriptional coactivator (Spoel et al. Cell 2009, 137:
p.860 & Fu et al. Nature 2012, 486: p.228). Further work has established
that ubiquitination and degradation play complex roles in regulating the
intrinsic activities of transcription (co)activators in general (Skelly
et al. Curr Opin Plant Biol 2016, 33: p.126). However, it remains
unclear how protein modifications by ubiquitin signal to the
transcription machinery and fine-tune gene expression at the single cell
level. Moreover, different types of protein ubiquitination have diverse
cell signalling roles but how they contribute to immune gene regulation
remains largely unknown. This position offers an exciting opportunity to
explore this emerging field with a suite of biochemical, -omics and
single cell microscopy approaches. You will be highly motivated, have
excellent communication skills, enjoy working in a multidisciplinary
team, and show commitment to delivering high quality data.

The position is for a fixed term of 3 years.

For more information and to apply:

Reader in Plant Sciences
Royal Society Research Fellow & GARNet Chair

University of Edinburgh
School of Biological Science
The King's Buildings
Max Born Crescent
Edinburgh EH9 3BF
United Kingdom

email: steven.spoel from ed.ac.uk
Phone: +44 131 650 7065
URL : http://spoel.bio.ed.ac.uk
URL : www.garnetcommunity.org.uk
The University of Edinburgh is a charitable body, registered in
Scotland, with registration number SC005336.

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