In article <1993Jan27.182937.12863 at gserv1.dl.ac.uk>
Bianca (HABERMANN at AIMP.UNA.AC.AT) writes:
| Suppose you had promotor sequences of several - functionally related - genes
| with a conserved sequence motif in common,
Two sequence recognizers can have identical consensus sequences, and yet
recognize different patterns. Therefore you should not use consensus
sequences. Instead, make sequence logos of the sequences you have at hand and
compare them to the sequence logos of other sites. The results will be highly
sensitive and mathematically much more sensible.
See:
@article{Stephens.Schneider.Splice,
author = "R. M. Stephens
and T. D. Schneider",
title = "Features of spliceosome evolution and function
inferred from an analysis of the information at human splice sites",
journal = "J. Mol. Biol.",
volume = "228",
pages = "1124-1136",
year = "1992"}
Regards,
Tom Schneider
National Cancer Institute
Laboratory of Mathematical Biology
Frederick, Maryland 21702-1201
toms at ncifcrf.gov
