New way to visualize specific proteins in living cells using fluorescence

[Peter Hug]

>Last year, Roger Tsien has described a new approach to a fluorescent
>vital dye for specific proteins.  It involves tagging the protein with a
>small tag which then serves as a target for a fluorescent pro-ligand:
>
>     4',5'-bis(1,3, 2- dithioarsolan-2-yl)fluorescein
>
>Griffin BA, Adams SR & Tsien RY.  (1998).  Specific covalent labeling of
>   recombinant protein molecules inside live cells.  Science 281, 269-272.
>
>Has anybody had luck with this new approach?

Also, is this dye available commercially?

Thanks,
Peter Hug