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genetic risk calculations

David Curtis dcurtis at hgmp.mrc.ac.uk
Wed Mar 22 05:36:29 EST 1995


In article <3koqpa$t83 at mercury.hgmp.mrc.ac.uk> ifenton at hgmp.mrc.ac.uk (I. Fenton) writes:

>we do this on a semi-regular basis, and it works fine.  you could
>also do a run with locus order "2 3 1" where your two markers are
>on one side of the disease gene, but i dont think that will give
>you much added information...

Depends on how informative your markers happen to be. If they're not 
very, then using two instead of one may provide a lot more info. (Depends also 
on things like how far away they are, and the particular pattern of disease 
and marker segregation in the pedigree, etc.)



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