IUBio

Journal Watch: MHC and intracellular self

Shiv Prasad shiv at tsp.med.umn.edu
Thu Aug 20 19:56:13 EST 1992


In article <92233.085821FORSDYKE at QUCDN.QueensU.CA> <FORSDYKE at QUCDN.QueensU.CA> writes:
>
>              You anticipate me! What determines a promoter, enhancer, mRNA
>              stability, and rate of translation?
>
This tangent is going too far into the nucleus for my knowledge.  I don't follow
how things such as zinc-fingers and CAAT boxes determine self from nonself in
the intracellular compartment.  Perhaps you could elaborate more on this.


>              What determines that protein A will live longer than protein B?
>
I really don't know, does anyone?
Conformation may have something to do with it, as some proteins may expose
protease sites.  But until the intracellular half-lives of proteins can be
compared to their 3-D structures this may just be conjecture.


Shiv

>>>>>References:   Forsdyke, D. (1992) Bionet.immunology 812 947edt
>>>>>              Prasad, S. (1992) Bionet.immunology 814 1516gmt
>>>>>              Forsdyke, D. (1992) Bionet.immunology 817 1757edt
>>>>>              Prasad, S. (1992) Bionet.immunology 818 133gmt
>>>>               Forsdyke, D. (1992) Bionet.immunology 818, 1616edt
>>>                Prasad, S. (1992) Bionet.immunology 819, 405gmt
>>                 Forsdyke, D. (1992) Bionet.immunology 819 1019edt
>>                 Prasad, S. (1992) Bionet.immunology 819, 2019gmt
		   Forsdyke, D. (1992) Bionet.immunology 820, 858edt
>



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