In article <1992Aug19.040540.21000 at news2.cis.umn.edu>, shiv at tsp.med.umn.edu
(Shiv Prasad) says:
>In article <92231.161618FORSDYKE at QUCDN.QueensU.CA> <FORSDYKE at QUCDN.QueensU.CA>
>writes:
>>>> Yes. So, what determines the concentration of self proteins in a cell?
>>>> Yes. So what determines the concentration of viral proteins in a cell?
>>Prasad: Synthesis - Turnover would give us the number of copies of protein X
Forsdyke: Yes, synthesis and degradation (turnover). OK. Now be patient and
tell me what determines rates of synthesis and degradation.
>> Under what conditions would the virus be in "excess"?
Prasad:
>Depends on the virus.
Forsdyke: OK. Let's just take a "generic" virus which goes about its
business within the cell and eventually lyses the cell.
It will make some viral proteins more than others, but a minimum
of one protein would be necessary in order to get a foreign
peptide displayed at the cell surface with MHC class I.
> Prasad: Goerge Chacko indicated earlier that homotypic adhesion
>was dependent on protein concentration, pH, and the notorious "other factors."
>Since we realy can't say for certain which proteins agggregate better at
>cellular pH, and how the "other factors" play a role, we seem to be left with
>[protein] as the only thing that we can grasp.
> Forsdyke: At this stage it should be noted that one of the "other factors",
as implied in my original test-tube scenario , is the concentration
of other proteins in the crowded cytosol. More of this later.
>>> Sincerely,
>> Don Forsdyke
>>>>References: Forsdyke, D. (1992) Bionet.immunology 812 947edt
>> Prasad, S. (1992) Bionet.immunology 814 1516gmt
>> Forsdyke, D. (1992) Bionet.immunology 817 1757edt
>> Prasad, S. (1992) Bionet.immunology 818 133gmt
> Forsdyke, D. (1992) Bionet.immunology 818, 1616edt
Prasad, S. (1992) Bionet.immunology 819, 405gmt
