In article <25JAN93.14413776 at wums.wustl.edu> wetsel_r at wums.wustl.edu writes:
>In a previous article, KJSHIV01 at ulkyvx.louisville.edu (KEVIN JAY SHIVELY/SCC) wrote:
>>Hello,
>> I am an undergraduate pre-med student at the University of Louisville.
>>I am currently enrolled in a graduate level immunology course. The problem is
>>we are to write a 10-30 page paper on some topic of interest in Immunology
>>that goes into a fair amount of depth. I am interested if anyone out there
>>might have some ideas on a possibly good topic and maybe even a few pointers
>>on finding some really good research journals. I am not wanting any responses
>>with offers of pre-fabricated papers....I always do my own work and do it well.
>>However, if anyone out there can help me with some good "starter" ideas it
>>would be greatly appreciated. Since this is my last semester and I have a
>>very full schedule I would rather not spend hours in the library just trying
>>to come up with an idea.
>>>>>> Thanks,
>>>> Kevin Shively
>>KJSHIV01 at ulkyvx>-----------------
>Kevin:
>>If it were me, I'd go for superantigens myself. It's facinating how SA's
>skirt around the specificity of the immune system and stimulate T cells
>that only bear a particular V-beta element. I'd keep the discussion
>limited to bacterial SA's as viral SA's are a bit more complex.
>>Start with Anal. Rev. Immunology 1991 with Kappler and Marrack. Do a
>medline on either one, and on superantigens (as a subject) itself. After
>that, there will be more than enough info to get you going...
>>Happy searching!
>>===========================================================================
>+ David L. Haviland, Ph.D. Internet:"haviland at kids.wustl.edu" +
>+ Washington Univ. School of Med. A.K.A : The Compiler +
>+ Dept. of Peds./Pulm. Box 8116 ICBM-Net : Just hit St. Louis +
>+ 400 S. Kingshighway &-6 <- User is Brain Dead... +
>+ St. Louis, MO 63110 FAX: 314-454-2476 +
>+ (314) 454-6076 +
>===========================================================================
>
Kevin,
If you go with superantigens, be careful in accepting wholesale
the conclusions of Kappler & Marrack. Although they ARE pioneers in the
field, they are also wildly speculative folks, and a number of their
conclusions are generally regarded as fantasy. Good luck! Edwin Rock
