In article <ahouse-140793110837 at 129.64.1.172> ahouse at hydra.rose.brandeis.edu (Jeremy John Ahouse) writes:
>Maybe lots of low affinity (=? multispicificity) receptor
>bearing cells are kept in check somehow by numbers and cytokine levels but
>are given a chance for clonal expansion and recruitment in the TGFbeta
>minus animals and so we "see" these clones in this case. hmmm...
>> Jeremy John Ahouse
Interesting hypothesis, especially if the low-affinity, autorx cells are
oligoclonal, and perhaps specific for a few housekeeping genes. I'm not
too familiar with the tissue involvement in the autoimmunity in the
TGF-b k/o mice, but that might be a possiblity.
Shiv
