Actually, the mice were born viable so TGF-beta production by the embryo must
not be a requirement. My question with regards to fetal recognition, is, is
it tolerance or sequestration? Don't pregnant mothers respond normally to
the relevant alloantigens in vitro and by skin graft rejection?
We have a transgenic mouse model in which allo class I is expressed
in the lens of the eye and nowhere else. In this case, there appears
to be no tolerance, but no recognition either, presumably due to the
sequestered nature of the lens.
