Did anyone happen to see the recent Nature article about a MHCII
dimer? The crystal was resolved around > 3 angstroms, but they did
find it as a dimer; alpha beta alpha beta. Wasn't it interesting to
see CD4 associated in their cartoon as a "stalk between the leaves"?
We wondered if this was a crystallographic peculiarity--
Also, did anyone read in the may issue of pnas, the very intriguing
study regarding the use of circular cdrh3's linked by cys as an
alternative to the entire fab/fc? We have proposed that cdrh3's
by themselves might be very important in determining fine
specificity. It was really neat to see that neutralizing effects
could be seen (although 10-2 less) with just a LOOP, rather than the
entire Fc.
George
