In article <f-norman.68.0 at nimr.mrc.ac.uk> f-norman at nimr.mrc.ac.uk (Frank Norman) writes:
>In article <2812 at rc1.vub.ac.be> philstas at vub.ac.be (Stas Philippe) writes:
>>There is a hybridoma database, containing information on
>>antigen-antibody specificities.
>>I'll check out if it still exists and mail later to the newsgroup.
>>There is a database called IMMUNOCLONES produced by CERDIC (Centre
>Europeen de recherches Documentaires sur les Immunoclones). It is available
>on the Datastar (commercial) online service based in Switzerland. Datastar
>are connected to Internet but you will need to register with them and obtain
>a password in order to use their system. It will also cost you money :-(
>Check whether your library have access to Datastar.
>>"The Immunoclone database contains data about cells of immunological
>interest such as hybridomas, trasnfectomas and T-cell clones and their
>products, monoclonal antibodies. The database contains descriptions
>including: cell types, immunogen, immunocyte donors, immortal partners and
>product information such as type and designation of the product and
>reactivities. Full bibliographic details are provided for each entry. "
>>>Frank Norman | National Institute for Medical Research
>Deputy Librarian | The Ridgeway, Mill Hill, London NW7 1AA
> |
>f-norman at uk.ac.mrc.nimr | tel 081 959 3666 ext 2380 fax 081 906 4477
>>f-norman at national-institute-for-medical-research.mrc.ac.uk>also.....
Hybridoma Data Bank
In 1983, The Committee on Data for Science and Technology (CODATA),
and the International Union of Immunological Societies (IUIS) established
an international Hybridoma Data Bank (HDB) to provide a comprehensive
directory of information on hybridomas and other cloned cell lines and
their immunoreactive products, such as Mabs. Data for this resource
are collected by multiple Nodes, or data collection and dissemination
centers, located in the U.S., Canada, Japan, and India. The U.S. Node
is managed by the Bioinformatics Department of The American Type Culture
Collection and is funded by the National Institute of Allergy and
Infectious Diseases (NIAID), the National Institute of Child Health
and Human Development (NICHD) and the Food and Drug Administration (FDA).
ATCC is responsible for collection and dissemination of data contained
in this resource. The overall HDB is monitored by a CODATA appointed
Task Group of immunologists and computer scientists who meet yearly with
the Node Managers to certify the scientific validity of the data. All of
the HDB Nodes use standardized format and terminology to store and exchange
data.
HDB maintains a controlled hierarchical list of terms which cover
virtually all of the subdisciplines of biology and organic chemistry.
Mabs can be generated that react with specific epitopes on molecules
comprising the organic structure of all types of organisms. These
molecules and their biological origins are described in the database.
The terminology used to describe the reactivity of Mabs covers the
taxonomy of each genus, species, and strain of organism, as well as
the cells, subcellular structures, organs, tissues, and biochemical
substances and their components that were derived from these organisms.
HDB records contributed by each collecting center are subjected to
stringent validation procedures to insure that the biological terminology
is consistent and that it follows guidelines set by nomenclature
standardization committees of the International Council of Scientific
Unions' Biological Unions (e.g., International Union of Biochemistry,
International Union of Microbiological Societies, International Union of
Immunology, etc.) whenever possible.
The HDB now contains data on over 28,000 immunoclones and their
products. HDB has been designed in a highly structured format and is
housed on the NIH computer using the relational database management
system, DB2. Reports can be generated from this system that are specific
for users' requirements. During 1993 we will be converting the HDB to a
SUN/Unix/Sybase environment and hope to have it available for direct user
query via the Internet. Until that time we will be happy to process queries
and forward retrievals to requestors via email, Fax, or regular mail. The
database is also online via several commercial hosts.
HDB holds data on various aspects of hybridomas and their immunoreactive
products. Information on a hybridoma's construction and the reactivity and
non-reactivity of its secreted product is included. In addition, information
on the availability of an individual hybridoma and its Mab product are
included. Information in the HDB is derived from literature, catalogs and
survey forms.
For further information contact: Barbara Lewis
Hybridoma Data Bank
blewis at helix.nih.gov
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Barbara Lewis blewis at helix.nih.gov Hybridoma Data Bank
