In article <94226.084939FORSDYKE at QUCDN.QueensU.CA> <FORSDYKE at QUCDN.QueensU.CA> writes:
[ . . . ]
> . . . there is the
>possibility that, over evolutionary time, each gene fine-tunes its protein
>concentration to the other proteins with which it has been travelling through
>time.
> Sincerely, Don Forsdyke
> Discussion Leader. Bionet.immunology
But. (1) If that were the case, surely the evolutionary pressure on
intracellular parasites would ensure that they too would produce their
proteins below the aggregation threshold, thus preventing antigen
presentation altogether.
(2) This discussion is based on the premise that normal
intracellular proteins are not presented and therefore an explanation
is needed as to why they aren't. . As I pointed out this is not
correct; normal proteins are presented, the process of thymic education
ensures that T cells do not respond to them.
Ian
