In article <2hme89$m9i at mserv1.dl.ac.uk>, mbwjm at s-crim1.dl.ac.uk (W.J.
Mawby) wrote:
>> dear all
> we are looking at the hinge region of an IgG1 and would like to
> model the structure, unfortunately a search of Brookhaven only gave us strucures
> lacking this region (both Fc and Fab). Is anybody working on this or has any
> information which would be useful to us.
AFAIK, the hinge region is *very* flexible, and no X-ray studies have yet
been puplished. I suspect very strongly that they will be more or less
impossible to obtain, but would *love* to be proved wrong. Modelled
structures (*maybe* from NMR, but otherwise pure modelling) are likely to
be your only bet, I'm afraid.
--
James Petts
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P.S. Please excuse my rottn' english you see moomins go to
school only as long as it amuses them.
