dLee (dLee at ccmail.llu.edu) wrote:
: Jane Harper writes:
: > I'd love to hear what the folks in this newsgroup
: > feel are the pivotal discoveries that have occurred _outside_ HIV
: > research have been for, say the past 15 years.
: >
: > Any takers?
: I would list the following as an "Immunology Top Ten":
: (IMHO, of course)
: in no particular order,
: 1) "The Groove"- MHC structure and peptide binding site
: 2) The Immunoglobulin superfamily as a general structural model
: for receptors
: 3) Structure of the T-cell receptor (and associated CD3)
: 4) Gene rearrangment as the mechanism for generation of diversity
: 5) Mechanism of Superantigens
: 6) Role of Cell Adhesion Molecules in leucocyte extravasation
: 7) Signal transduction models for B and T cells (Ca++, IP3, tyr-p)
: and related identification of many tumor genes (myc, fyn, etc)
: 8) NF-kappaB/AP-1 and other related molecules in
: transcriptional regulation
: 9) Deletion of self-reactive TCR in the thymus as the mechanism
: for central tolerance
: 10) Positive selection as the mechanism behind MHC-restriction
I would also include the importance of T lymphocyte costimulation
(and lack of it causing T cell tolerance).
What do others feel?
______________________________________ _________________________________
[ Lee Wetzler || ]
[ The Maxwell Finland Laboratory || e-mail lwetzler at acs.bu.edu ]
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