In article <30ae89$v0d at bigblue.oit.unc.edu> njs at med.unc.edu (Neil Slater) writes:
> I would appreciate any info (or references) on possible molecular basis
>of somatic mutations within immunoglobulin genes. I have done a medline
>search but have not had a lot of luck at finding anything solid.
>> Thanks in advance,
>> Neil Slater
That's because you're trying to get information on one of the few "big
picture" problems left to be solved in molecular immunology. There just isn't
much known about how it occurs. Why it occurs? Probably. When it occurs,
yes. But not how it occurs. No real progress there, unfortunately. You may
find hypotheses (DNA pols with error-prone features built in, gene conversion,
etc., but nothing for which there's good evidence).
Stacy
