Nude mice: immune defects other than T cells ?

[Thierry Sornasse]

Hi Immunenetters,

I study the possible influence of T cells on the maturation of DC. Since Nude
mice have a little number of fonctionnal T cells, I work with type of mice.
Although, I am wondering if the Nude mutation has other affects on other cells
type of the immune system.

I know that some authors suggest that B cells of Nu/Nu mice are not normal but is
there any evidence for that ?
I would like also to know if other cell types like monocytes/macrophages,
granulocytes, NK cells, mastocytes are affected by the Nu mutation ?

Thank you in advance for your help

Bye

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