I'm trying to construct a chimeric receptor and I would like input on a
suitable extracellular portion. I would like it to be as small as possible,
since the vector I am using has a size constraint (it should be about 1-1.5
kb max for the extracellular portion). Other criteria: it should only be
present on specialized cells, and have commercially available ligand and
antibody. Originally I was using the cFMS receptor (CSF-1 receptor) but it
is too large. Any advice would be appreciated.
Sue Jeffrey
Memorial Sloan-Kettering Cancer Center
New York City
email: sjeffrey at ski.mskcc.org