Zafer Yildirim (zxy5 at po.CWRU.Edu) wrote:
: I just wanted to get your ideas about a question I have no answer
: All T cell lines ( other than T cell clones which are not of
: tumor origin ) are CD4+. I have never seen a CD8+ tumor cell line
: and I have been wondering why? Any comments?
I believe that CD8+ cells are dependent on interleukin-2 which
they obtain from production by CD4+ cells. Why the addition
of exogenous IL-2 is not sufficient, I'm not sure. Offhand, I
might suspect the involvement of other CD4+ cytokines.
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Psycler @T@~