ANNOUNCING THE FIRST GORDON RESEARCH CONFERENCE
ON NITRIC OXIDE IN BIOCHEMISTRY AND BIOLOGY
Jan. 29-Feb. 3, 1995
Holiday Inn
Ventura, California
CO-CHAIRMEN: Dr. Jack R. Lancaster, Jr., Departments of
Physiology and Medicine, LSU Medical Center, and Dr. William J.
Payne, Department of Microbiology, University of Georgia
CO-VICE CHAIRMEN: Dr. Louis J. Ignarro, Department of
Pharmacology, University of California Los Angeles, and Dr. Jean
LeGall, Department of Microbiology, University of Georgia
This meeting will focus on the fundamental mechanisms of the
interactions of NO with cellular targets and the enzymology of its
synthesis/metabolism. The conference will be the first gathering of
researchers studying NO in mammalian, plant, and microbial systems
and will have a heavy emphasis on the chemistry/biochemistry of NO.
As with all Gordon Research Conferences, major emphasis is placed on
the interactions of attendees, both during sessions and in the
afternoons (which are free). The topics chosen for oral presentations
are intended to stimulate these discussions.
Information and application forms available from the October 14, 1994
issue of Science. Application forms must be sent to the GRC office no
later that the middle of December, and early submission increases
likelihood of acceptance (attendance is limited to approx. 120 attendees,
including speakers).
SESSION 1:
Mon. 1/30
am: OVERVIEWS: CHEMISTRY AND BIOLOGY OF NO
(Joseph Beckman (Birmingham), Discussion Leader)
J. Lancaster (New Orleans)
"History and Overview of Nitric Oxide in
Mammals"
W.J. Payne (Athens)
"Microbial and Plant Metabolism of NO"
L. Ignarro (Los Angeles)
"The Nitric Oxide-Cyclic GMP Signal
Transduction Pathway"
SESSION 2:
Mon. pm: DETECTION AND ANALYSIS OF NO (W.J. Payne
(Athens), Discussion Leader)
Speaker TBA
T. Malinski (Rochester) (Title TBA)
SESSION 3:
Tue. 1/31
am: MOLECULAR SITES OF NO INTERACTION I.
METALS (J. Lancaster (Pittsburgh), Discussion
Leader)
A. Thomson (Norwich, UK)
"NO Binding to Non-Haem Iron and Copper
Sites in Proteins"
B.-H. Huynh (Atlanta)
"Mossbauer Characteristics of Cytochrome
Nitrite Reductases and their NO Derivatives"
Y. Henry (Paris)
"EPR Characterization of Metalloproteins as NO
Targets in Cells and Organelles"
SESSION 4:
Tue pm: MOLECULAR SITES OF NO INTERACTION II.
OXYGEN AND NITROGEN (M. Feelisch (Monheim),
Discussion leader)
J. Beckman (Birmingham)
"The Interactions of Nitric Oxide, Superoxide
and Peroxynitrite in Dilute Solution"
D. Wink (Frederick)
"The Chemical Biology of NO. Insights into
Protective and Toxic Mechanisms for
Therapeutic Applications"
S. Tannenbaum (Cambridge)
"The Chemstry of NO-Induced Cytotoxicity and
DNA Damage"
SESSION 5:
Wed. 2/1
am MOLECULAR SITES OF NO INTERACTION III.
SULFUR (L. Ignarro (Los Angeles), Discussion
Leader)
M. Feelisch (Monheim)
"Interactions of Nitrogen Oxides with Sulfhydryl
Groups and its Implications for the Modulation
of Cell Function and Cell Communication"
J. Stamler (Durham)
"Interactions of NO with Thiol Groups: Role in
Cellular Defense"
J. Fukuto (Los Angeles)
"The Possible Role of Thiols in NO Synthase
Catalysis"
SESSION 6:
Wed. pm: ENZYMOLOGICAL GENERATION OF NO. I (J.
LeGall (Athens), Discussion Leader)
W. Zumft (Karlsruhe)
"Bacterial Nitric Oxide Reductase: An Ancestral
Enzyme?"
T. Michel (Boston)
"Post-Translational Regulation of Endothelial
Nitric Oxide Synthase"
SESSION 7:
Thur. 2/2
am: ENZYMOLOGICAL GENERATION OF NO. II (W.
Zumft (Karlsruhe), Discussion Leader)
B. Mayer (Graz)
"Role of Tetrahydrobiopterin as Cofactor in
Nitric Oxide Synthase"
E. Adman (Washington)
"Structure and Site-Directed Mutagenesis
Studies of Copper Nitrite Reductases"
D. Stuehr (Cleveland)
"Multi-Level Control of Electron Transfer in the
NO Synthase"
SESSION 8:
Thur. pm: Keynote Address: John B. Hibbs, Jr. (Salt Lake City,
UT) (Title TBA)
SESSION 9:
Fri. 2/3
am: ENZYMOLOGICAL GENERATION OF NO. III (D.
Stuehr (Cleveland), Discussion Leader)
B. Masters (San Antonio)
"Molecular Dissection of Neuronal Nitric Oxide
Synthase Using Recombinant DNA Techniques:
Evidence for Gene Fusion"
S.J. Ferguson (Oxford)
"Synthesis and Reduction of Nitric Oxide by a
Denitrifying Bacterium"
Thur. afternoon: "Hot Topics"; Short presentations selected from
abstracts presented at the beginning of the
meeting.
