I would like to know what people think is the greatest advance in
immunology in the last 25 years. My opinion is that it is the two signal
model of lymphocyte activation, first proposed by David Dresser, then Don
Forsdyke (if I'm not mistaken, he is the founder of this usenet group),
then championed by Peter Bretscher and Mel Cohn and, for T cells, by
Kevin Lafferty and Alistair Cunningham. A distant second would be the
discovery of MHC restriction of T cell responses by Peter Doherty and
Rolf Zinkernagel.
