In Article <CvICoL.1KMr at hawnews.watson.ibm.com>, jjb at watson.ibm.com (John
Barton) wrote:
> I have read many accounts of the chemical signals sent to
>alert the components of the immune system. Unfortunately, such
>articles never seem to specify how the system localizes response.
>Does the immune system flood the body with T-cells and rely on
>statitisical encounters and local activation or do T-cells get up
>and hike over to the fire?
T cells explore tissues by crawling over and under other cells in search of
antigen/MHC complexes specific for their T cell receptors (for example see
Chang, et al., PNAS 76:2917; 1979).
