Well, no, they don't swim. But they do tumble, roll, stick, flatten,
ruffle, squeeze, and crawl. For more info on what's known, please
check out at least the following:
Springer TA.
Traffic signals for lymphocyte recirculation and leukocyte emigration:
the multistep paradigm.
Cell, 1994 Jan 28, 76(2):301-14.
(UI: 94123337)
Pub type: Journal Article; Review; Review, Academic.
Jutila MA.
Function and regulation of leukocyte homing receptors.
Journal of Leukocyte Biology, 1994 Jan, 55(1):133-40.
ABSTRACT available. (UI: 94110734)
Pub type: Journal Article; Review; Review, Tutorial.
Later,
Aaron
In article <34de3r$973 at scratchy.reed.edu>,
Aaron J Mackey <amackey at reed.edu> wrote:
>In article <CvICoL.1KMr at hawnews.watson.ibm.com>,
>John Barton <jjb at watson.ibm.com> wrote:
>> I have read many accounts of the chemical signals sent to
>>alert the components of the immune system. Unfortunately, such
>>articles never seem to specify how the system localizes response.
>>Does the immune system flood the body with T-cells and rely on
>>statitisical encounters and local activation or do T-cells get up
>>and hike over to the fire?
>>>>--
>>John.
>>>>John J. Barton jjb at watson.ibm.com (914)784-6645
>>H1-C13 IBM Watson Research Center P.O. Box 704 Hawthorne NY 10598
>>In article <3481eb$l90 at agate.berkeley.edu> you write:
>>Although T cells probably cannot "swim", as we think of it (i.e. move
>>directionally when suspended in liquid), they definitely can crawl. T cells
>>use pseudopodia (like amoebae) to move along a surface. Thus, a T cell that
>>Really? I have never heard of this before, do you have reference to this
>phenomenon you could forward to me, I would be much interested.
>>>is in a small capillary can crawl along the inner surface toward a signal,
>>and T cells that are in other tissues (as in an immune response) can use the
>>extracellular matrix as a crawling surface.
>>>>BioKen
>>I think an even better answer to the question is the fact that T cells have
>cell surface markers which act as homing devices to certain tissues. An
>activated T cell may up regulate its expression of a certain cell surface
>receptor which allows it to travel through the blood stream until it reaches
>the site of action, i.e. a directed statistical encounter in the sense that
>the binding affinity of the homing molecule will assure that the cell binds
>where it is supposed to and no where else.
>>Just my two cents worth.
>>Aaron Mackey
>Reed College
>Portland, OR 97202
>>>>--
>>Ken Frauwirth (MiSTie #33025) _ _
>>frauwirt at mendel.berkeley.edu |_) * |/ (_ |\ |
>>Dept. of Molec. & Cell Bio. |_) | () |\ (_ | \|
>>Univ. of Cal., Berkeley "Well, I isolated that nucleotide today."
>>
