In article <Ken_Nguyen-0908950133440001 at cis-ts4-slip15.cis.brown.edu>,
Ken_Nguyen at brown.edu (Khuong Nguyen) wrote:
> > In article <3vr3rf$r3h at saffron.hnrc.tufts.edu>, Jim Sadowski
> > <Sadowski_VK at HNRC.Tufts.edu> wrote:
> >
> > > Does anybody know where I can find a program for predicting antigenic
> > > epitopes from protein sequences for determining the best peptides for
> > > immunization? Thanks.
> > >
> > > Jim Sadowski, Ph.D.
> > > Jean Mayer USDA Human Nutrition Research
> > > Center on Aging at Tufts University
> > > Sadowski_VK at Mint.HNRC.Tufts.edu>> You can also try Anne DeGroot at Brown University. She has a computer
> algorithm predicting putative T cell epitopes. You can contact her at
>degas at brownvm.brown.edu -ken nguyen
!!!!!!
Beware that antigenicity and immunogenicity are not the same. Programs
that predicts antigenicity - B-cell epitopes - are numerous see also
Peptide Antigens - A practical approach Edited by G.B.Wisdom Chapter
review article (ISBN 0-19-963451-3 IRL Press)
Programs that predicts T-cell epitopes - immunogenicity - can hardly be
used with confidence
- Soren Ostergaard
