IUBio

Antibody/Antigen Structure (fwd)

opt018 opt018 at nof.abdn.ac.uk
Wed Jan 11 06:04:27 EST 1995


Hao Xiao (haoxiao at cc.UManitoba.CA) wrote:
: Four major forces are involved. 

: London disperse forces: like moon (Ag) and earth (Ab), can not be too close 


: Hydrophorbic force: act like your ruber sticker on the glass wall. you squeeze

: Hydrogen and ionic bonding: act like your magnet sticker. Such forces 
-----

Nice explainations. 

----

Question 1: Can London disperse force and Hydrophorbic force coexist in the same
Ag/Ab complex pair?

Question 2: You mentioned that you can increase the affinity by slightly
increase the Ag size, simply because 'more water molecules are squeezed out'. 
Does this contradict the fact that Ab only recognize a certain fragment of Ag
specifically, no matter how big the Ag size is? 

Question 3: What is the forth major force? :-)


Thanks a lot. 



--------------------

Yours 

Y-F D. Cheng, MB ChB
Dept Ophthalmology
Univ Aberdeen
UK

<opt018 at aberdeen.ac.uk>
<http://www.abdn.ac.uk/~opt018/cheng.html>





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