In our lab, we are working with variants of the BW5147 T lymphoma, for which
the syngeneic hosts are AKR mice. To determine the contribution of T cells
versus NK cells in the host response towards the tumor cells, it is customary
to inject the cells in immuno-compromised animals, such as SCID mutants (no
T or B cells), beige mutants (no NK cells) or SCID/beige mutants. Until now,
we have been working with SCID mutants from BALB/c origin. However, to avoid
artefacts due to a differential response by allogeneic NK cell populations,
we would like to work in syngeneic recipients now.
Our question is now: does any one of you know if it is possible to obtain
SCID, beige and/or SCID/beige mutants in AKR mice and if so, where?
Many thanks in advance.
