IUBio

Antibodies against free heavy chain of HLA class I

John Ladasky ladasky at leland.Stanford.EDU
Tue Jul 4 22:12:29 EST 1995


In article <3tbktl$9ju at saba.info.ucla.edu>,
David Yu  <dyu at med1.medsch.ucla.edu> wrote:
>I am looking for monoclonal antibodies against free heavy chain 
>of HLA class I protein to study expression on cell surface.

	Look for the antibodies HC10 and LA45.  A recent reference to the
former is:

	Little AM; Nossner E; Parham P.
	Dissociation of beta 2-microglobulin from HLA class I heavy chains
	correlates with acquisition of epitopes in the cytoplasmic tail.
	Journal of Immunology, 1995 May 15, 154(10):5205-15.

And a recent reference to the latter is:

	Madrigal JA; Belich MP; Benjamin RJ; Little AM; Hildebrand WH;
	Mann DL; Parham P.
	Molecular definition of a polymorphic antigen (LA45) of free
	HLA-A and -B heavy chains found on the surfaces of activated B
	and T cells.
	Journal of Experimental Medicine, 1991 Nov 1, 174(5):1085-95.

Good luck!
-- 
Unique ID : Ladasky, John Joseph Jr.
Title     : BA Biochemistry, U.C. Berkeley, 1989  (Ph.D. perhaps 1998???)
Location  : Stanford University, Dept. of Structural Biology, Fairchild D-105
Keywords  : immunology, music, running, Green



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