There are no rules here. Induction of tolerance or immunity depends on
many factors-antigen dose, form, ability to be transported across the gut
epithelium, etc. You can't assume that one factor like dose will
determine whether you get tolerance or response. The dogma that oral
ingestion of antigen leads to tolerance is a myth. Oral immunization is
like any other route of immunization; multiple factors determine the
immunologic outcome. So go ahead and make your vaccine in plants; later
on you'll have to figure out how to get it properly presented to the
immune system by examing the effect of dose, formulatin, etc.
Jerry Pier
In article <3thmep$135 at mail>, bLangridge at ccmail.llu.edu (Bill Langridge) wrote:
> I am interested in making a vaccine in plants for the development of
> oral immunity. It seems that a small amount of antigen will cause
> immunotolerance rather than immunity which could also be useful. Can
> someone tell me if there are accepted amounts of an antigen which will
> induce a systemic immunity rather than immunotoleramce?
