IUBio

Cleavage of MHC class II by trypsin

Ian A. York york at mbcrr.dfci.harvard.edu
Mon Jul 31 18:58:48 EST 1995


In article <199507311843.NAA04442 at wugate.wustl.edu> ksabelko at PHARMDEC.WUSTL.EDU (Kim Sabelko) writes:
>
>Does anyone know if trypsin can cleave MHC class II molecule off of cell
>membranes.  

I had the same concern and I was told not to worry about it; MHC II is 
highly resistant to most proteases.  After all, they pass through the 
endosomal pathway on their way out, and manage to do pretty well in spite 
of the fact that other proteins are geenrally chewed up.

Ian
-- 
Ian York   (york at mbcrr.harvard.edu)
Dana-Farber Cancer Institute, 44 Binney St., Boston MA 02115
Phone (617)-632-3921     Fax  (617)-632-2627




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