Would anyone have any comments, information or papers on the following!
1) I am interested in the "load" that the murine immune system can handle
during an infection or antigenic challenge. Specifically, how much
antigen does it take, and can antigen saturate the humoral or cellular
antigen-specific immune responses. Does it matter if the antigen is
the result of a systemic, tissue viral-infection, or is an injected
antigen such as myosin or sheep RBCs. Is for example, the antigenic
response to antigen "B" diminished if X ug of antigen "A" is
injected 2-3 days prior to antigen "B." During a viral challenge,
is a depressed immune response to a third party antigen (sRBC) due to
saturation of the immune system or potential viral disruption of
immune function?
2) I am also interested in the preferential recruitment of
circulating immune cells to the spleen in an naive and antigen primed
animal. I am aware of the fine architecture of the spleen and
lymph nodes and am interested in recent or old data on the selective
migration of marginal zone macrophages, red pulp macrophages,
follicular macrophages, inmature and mature B-cells and T-cells, and
the recruitment or "trapping" of such cells by macrophages, metalophilic
macrophages, FDC, and/or IFDC.
If anyone has comments, hypothesis, keywords, authors,
and/or articles, I would enjoy discussing the subject!
Thanks in advance,
Dan Anderson, graduate student
The University of Nebraska Medical Center/The University of British Columbia
Cardiovascular Research Laboratory
St Paul's Hospital
Vancouver, B.C.
