In article <ralph.1152923375B at 128.196.137.12> Ralph M Bernstein,
ralph at ccit.arizona.edu writes:
>the processing and presentation of an _epitope_, such as in the case of
our
>work, natural human autoantibodies, may be frame work1 peptides, etc-
never
>the whole idiotype. again, b cells cannot read.
Ab variable region is due to rearrangement and therefore different aa
structure. It is true this is folded into a 3d structure which interacts
with the Ag. But why can this aa sequence not be presented via the MHC
in small peptides and elicit an immune response since they are novel
sequences.? Remember T cells are able to distinguish single aa changes
in small peptides. It is an intriquing question.
