In article <3r3u39$3h7 at jhunix1.hcf.jhu.edu> Ephraim Fuchs,
ejf at welchlink.uoregon.edu writes:
>So once again I ask, How do T cells distinguish foreign antigens from
>idiotypes presented by B cells? Why should the former activate and the
>latter not?
DANGER DANGER .
Since you originally described this phenomena I believe you have thought
of this. I assume you believe that the B cell idiotype specific T cells
have been deleted/anergized prior to infection and therefore do not
react. But in an active infection when you have DANGER you also have a
huge amount of B cell somatic mutation generating new idiotypic peptides
in a proper mileu. Why do these not induce T cell response, or do they?
