Ralph M Bernstein (ralph at ccit.arizona.edu) wrote:
: i beleive that dr fuchs described the response to gram
: - bacteria as b cell only. no tcells. ohwell.
I believe that the burden of defense against gram - bacteria rests
squarely upon the neutrophil, and that the adaptive immune system plays
either no role or one that is detrimental to the host.
This is one reason why I believe that Charlie Janeway's hypothesis about
the immune system discriminating infectious nonself from noninfectious
self is incorrect. There is no immunologic memory to gram - bacteria,
and the notion that the adaptive immune system adapted pattern
recognition receptors (like the LPS receptor) on cells of the innate
immune system to become receptors that induce costimulatory signals for
naive T cells is simply hogwash.
Ephraim Fuchs
