re ^ 4 real function, gram neg, really?

[Dr M.R. Clark]

In article <ralph.1153115078B at 128.196.137.12>,
Ralph M Bernstein <ralph at ccit.arizona.edu> wrote:
>
>    hmm, 1) what about the reaction of (cross reaction) of gram negatives to
>the gut lymphocytes (classical vertebrate type immune response (noninate),
>tcell help for antibody production), and the potential causation of reaction
>to abo blood grouping.  sounds like memory to me.  
The immunoglobulin response to ABO blood groups is very restricted. There is
no class switching to IgG and if there was then it would cause tremendous
problems for ABO mismatched feotuses! This would cause problems way beyond
those of Rh incompatibilities! Not a very good example of memory of a T
dependent B-cell response.

Mike Clark, mrc7 at cam.ac.uk          http://www.path.cam.ac.uk/MikeClark/
--
  o/ \\    //            ||  ,_ o   Mike Clark, C.U. Dept. Pathology
 <\__,\\  //   __o       || /  /\,  "to pay for my hobbies I teach
  ">    ||   _`\<,_    //  \\ \> |  immunology and engineer antibodies :-)"
   `    ||  (_)/ (_)  //    \\ \_