I have some questions.
To explain tolerance, some mechanisms has been proposed - clonal
deletion, anergy, and active inhibition by suppressor T cells. Tolerance
is long lasting phenomenon, so I suppose that only active inhibition by
suppressor cells can play role in all cases of tolerance. I can imagine
here that the information what will be tolerated is saved in memmory
cells derived from suppressors. But where to store information in case of
clonal deletion and anergy? DO YOU AGREE?
What is the role of NK cells in regulation of immunity?
Do you know any stimulator of NK cells?
Linomide, synthetic immunomodulator, was used successfully in treatment
of some autoimmune diseases (animal models and clinical trials). This
compound stimulates NK cells. How this phenomenon could be connected with
influence of this drug on autoimmune diseases?
Thank you in advance for your answer.
Jan Zenka
zenka at limax.paru.cas.cz
