A postodoctoral position is available in the Boston University School
of Medicine to study molecular mechanisms of apoptosis in
lymphocytes. Particular emphasis will be placed on the role of a recently
described, nuclear receptor (the aryl hydrocarbon receptor/Ah R; see Science,
268:722) in inducing apoptosis in lymphocytes. Our recent work indicates that
ligation of this receptor by environmnental pollutants induces lymphocyte
apoptosis mediated by intracellular signals similar to those which mediate
lymphocyte apoptosis following antigen-receptor ligation. Two major objectives
will be: 1) to generate Ah R transgenic mice using Ah receptor gene knock-out
mice as a background and 2) to evaluate Ah recptor polymorphism in
humans. Approaches to be taken include gene cloning, sequencing, and
transfection, site-directed mutagenesis, and production of gene knock-out and
transgenic mice. Candidates with previous postdoctoral experience in these and
other areas of molecular biology are encouraged to apply. The successful
candidate will join a highly active and productive laboratory of 7
investigators with expertise in molecular and cellular biology. Collaborations
with several other laboratoriies at Boston University and Harvard Medical
School and may be exploited by the successful candidate. Significant
opportunity for additional, independent funding exists and should be viewed as
a chance to significantly advance the candidate's independent
career. Candidates with an enthusiasm for scientific discovery in a highly
supportive team environment and candidates who seek an opportunity to advance
their independence are encouraged to apply. Enthusiasm for baked beans is
optional. This position is available immediately and selection will be
complete by the end of June. Mail C.V. to: David H. Sherr, Ph.D., Professor of
Pathology, Professor of Environmental Health, Boston University School of
Medicine, 80 East Concord St. (S-105), Boston, MA, 02115 or E-mail to
dsherr at bu.edu.
--
David H. Sherr, Ph.D.
Professor of Environmental Health
Professor of Pathology and Laboratory Science
