Dave McNeill (dave at davemac.demon.co.uk) wrote:
: There is a tyrosine kinase, p56lck, binds
: >to the cytoplasmic portion of the CD4 receptor resulting in tyrosine
: >phosphorylation of the TCR zeta chain(s) (?).
: >At the same time, the TCR cytoplasmic region binds
: >another tyrosine kinase molecule, I think called p59fyn which also results
: >in tyrosine phosphorylation. Phospholipase C becomes activated leading to
: >hydrolysis of PIP2 into DAG (?), which then activates PKC, and IP3 in
: >turns raises the intracellular Ca+. In the end, the transcription of the
: >IL2 gene is able to take place.
: >
: >Since this is not so fresh in my mind, I do stand to be corrected. Any
: >signal transductionists care to take a shot?
: Almost there. Take another look at your textbook- its in there
: somewhere! (I could recomend a good one, but that may be seen as
: advertising) Or you could read Weiss, Cell 76, 263-74 1994.
Sorry, I don't have a textbook, only what's coming straight out of
my head along with all the disclaimers that you deleted. I'm 12
years post-grad, so if you have something to contribute, I'd
appreciate it. It's not my area of expertise or interest, but there
was another poster seeking the information. Thanks.
TKendrick
