A postdoctoral position is available in the Boston University School
of Medicine to study molecular mechanisms of apoptosis in
lymphocytes. Particular emphasis will be placed on the role of a recently
described, nuclear receptor (the aryl hydrocarbon receptor) in inducing
apoptiosis and in lymphocyte development. Our recent work indicates that
ligation of this receptor by environmental pollutants induces lymphocyte
apoptosis mediated by intracellular signals similar to those which mediate
lymphocyte apoptosis following antigen-receptor ligation. Furthermore, results
with Ah receptor knock-out mice indicate that the Ah receptor plays a role in
lymphocyte development. Two major objectives will be: 1) to generate Ah
receptor transgenic mice and 2) to evaluate Ah receptor polymorphism in
humans. Approaches to be taken include gene cloning, sequencing, and
transfection, site-directed mutagenesis, and production of gene knock-out and
transgenic mice. Candidates with previous postdoctoral experience in these and
other areas of molecular biology are encouraged to apply. The successful
candidate will join a highly active and productive laboratory of 7
investigators with expertise in molecular and cellular biology. Collaborations
with several other laboratories at Boston University and Harvard Medical
School have been established and may be exploited by the successful
candidate. Signifcant opportunity for additional, independent funding exists
and should be viewed as a chance to significantly advance the candidate's
independent career. Candidates with an enthusiasm for scientific discovery in
a highly supportive team environment and candidates who seek an opportunity to
advance their indpendence are encouraged to apply. Enthusiasm for baked beans
is optional. This position is available immediately and selection will be
complete by the end of June. Mail C.V. to: David H. Sherr, Ph.D. Professor of
Pathology, Professor of Environmental Health, Boston University School of
Medicine, 80 East Concord St. (S-105), Boston, MA 01115 or E-mail to:
dsherr at bu.edu.
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David H. Sherr, Ph.D.
Professor of Environmental Health
Professor of Pathology and Laboratory Science
