Dear fellow researchers,
I'm studying two antibodies, which have the peculiarity of staining the
cytoplasm or the nucleus of neural cells. They do this both on on frozen
tissue slides and on cultured cells.
For such a staining to occur, I presume that the antibody should first
bind to a membrane receptor, than be internalized. This can occur when a
Fc receptor is present, but, to my knowledge, neural cell do not have
such a receptor. Does anybody know examples of internalization of
antibodies outside the immune system, or can give an explanation for the
behaviour of these two antibodies?
I would be very grateful for any advice.
Thanks in advance.
Giorgio
