David Peritt <Peritt_d at a1.mscf.upenn.edu> wrote:
>In article <477dq3$fhg at hippo.shef.ac.uk> Catherine McIntyre,
>C.A.Mcintyre at Sheffield.ac.uk writes:
>>Does anyone have any ideas of how a human CTL response is perpetuated in
>>vivo?
>>If you mean during a response then the presence of antigen. If you are
>reffering to memory CTL then do you believe in persistance of antigen??
>If so it is easy to invision. If not good question.
Wasn't there an article in Science a year or two ago that demonstrated
perpetuation of memory T-cells thru low level activation by cross-
reactivity. I believe this was accomplished by transferring antigen
activated T-cells to mice which did not express the antigen. I can't
recall the authors or the exact model, however.
Regards,
bryan fisk
