Kupfer has shown Th actually focally secrete their IL-4 in a very
directed manner (JEM 179, 1507-1515, 1994). Bill Paul calls this the
"immunological synapse". The idea is that their is intimate association
between the Th cell and in this case the B cell. It seems likely similar
associations exist between Th and CTL.
Calman Prussin
Laboratotry of Allergic Disease
NIAID, NIH
