bryan fisk <bfisk at thesis1.med.uth.tmc.edu> wrote:
>David Peritt <Peritt_d at a1.mscf.upenn.edu> wrote:
>>In article <477dq3$fhg at hippo.shef.ac.uk> Catherine McIntyre,
>>C.A.Mcintyre at Sheffield.ac.uk writes:
>>>Does anyone have any ideas of how a human CTL response is perpetuated in
>>>vivo?
>>>>If you mean during a response then the presence of antigen. If you are
>>reffering to memory CTL then do you believe in persistance of antigen??
>>If so it is easy to invision. If not good question.
>>Wasn't there an article in Science a year or two ago that demonstrated
>perpetuation of memory T-cells thru low level activation by cross-
>reactivity. I believe this was accomplished by transferring antigen
>activated T-cells to mice which did not express the antigen. I can't
>recall the authors or the exact model, however.
>>Regards,
>bryan fisk
>
Could an article by A. Mullbacher be what you're looking for? Persistence of memory CTL in the absence of antigen. Can't remember the exact reference.
Does this help?
N.Newcombe
