IUBio

Help on Natural Killer Cells

Monica Ranes Goldberg msgold at ix.netcom.com
Wed Sep 20 23:31:23 EST 1995


In <43k3dv$mbr at netnews.upenn.edu> David Peritt
<Peritt_d at a1.mscf.upenn.edu> writes: 
>
>In article <43hvho$70j at cocoa.brown.edu> Gary C. Pien,
Gary_Pien at brown.edu
>writes:
>>specific T cell receptor (TCR) 
>
>  
>>Thus, the target specificity of NK cells is greater than that for
CTLs. 
>
>Why is target specificity greater in NK over CTL's?  So how do NK
cells
>know self from foreign?  The negative signaling of the class I like
>recognition structures is an interesting begginning.

See Science Vol. 267, February 17, 1995 p.978 and p.1016....NK cells
are responsive to an "absence of self"...




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