Dear fellow netters,
I wonder if someone could answer this question that came to me AFTER
hearing a talk on peripheral tolerance:
What kind of T-cell receptor to T-cell receptor transgenic mice express
on their T-cells? I figured the single T-cell should express both
receptors, the indigenous and the transgenic, but I wonder if there is a
kind of bilateral exclusion so that only one kind of receptor is
expressed and therefore there would be a subpopulation of T-cells
expressing the transgenic receptor. Does anyone know to what percentage
this subpopulation can build up to?
Thanks in advance for any input!
Volker
--
Dr. Volker Blaschke
Depts. of Biochemistry, Dermatology
Georg-August-University, Goettingen, Germany
Email: vblasch at gwdg.de
Tel: xx49 551 39 5959 / 5978