IUBio

are male and female sperm immunologically distinguishable?

M. Doherty M_Doherty at NIH.gov
Mon Jul 15 11:39:21 EST 1996


In article <9607122341.AA2199 at cmbexternal.biogen.com>,
Tom_Parish/Cambridge/Biogen.BIOGEN at BIOGEN.COM (Tom
Parish/Cambridge/Biogen) wrote:


> 
> I have heard that Yale University has a centrifugation process for separating 
> the sperm for parents who want to predetermine the sex of their child.  The 
> sperm are then delivered by artifical insemination.  I have no idea what
their 
> success rate is for this process.

The separation is based on the "fact" that Y sperm are supposed to swim
faster than X sperm, so that the preparation is enhanced for Y sperm.  The
success rate is apparently above 50%, so perhaps there is something in it,
although it is far from absolute.

As an interesting aside, I talked to a colleague (Ob/Gyn) who specialises
in the immunology of pregnancy - whne I quizzed her about the expression
of H-Y on sperm, she gave the standard answer that I passed on previously
- then said - "But actually, you know, I don't think that's ever been
tested rigorously"

So if anyone has a grad student needing an interesting immunology project
- all the necessary reagents appear to be available.

Cheers, Mark



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