Some authors found interesting correlations between NK cell receptors and MHC
Class I alleles, namely HLA-C, assigning some of these alleles as inhibitors
to lysis mediated by NK cells.
Aminoacids at specific positions (77 and 80 of the alfa helice of HLA-C
molecules) seems to play an important role.
My questions are:
1) makes sense to look at kidney transplant patients and their donors,
searching for identities in this NK groups (HLA-C typing), to explain
improvement on graft survival?
2) what would be expected?
3) how far can we go, knowing that MHC Class II identity is the first choice
in all HLA-matching policies?
4) perhaps the first, what would we expect from NK cells in this type of
tranplant, compared to bone marrow transplantation and others.
Thank you in advance for your comments.
--
Paulo Santos
LUSOTRANSPLANTE Fax +351-39-33674
Centro de Histocompatibilidade do Centro Telefone +351-39-33693
Apartado 3004 P-3049 COIMBRA Codex PORTUGAL +351-39-20527
