In article <199604292102.OAA23795 at net.bio.net> lcollado at BUZON.MAIN.CONACYT.MX (COLLADO VIDES LIGIA) writes:
>Dear neters:
>>I have the following data about the growth of the Kabat's Ig database:
>>Number of
>sequences
>>Year Heavy Ligth
>1965 0 0
>1966 0 2
>1967 2 25
>1968 4 12
>1969 3 15
>1970 16 32
.....
>1990 431 350
>1991 686 454
>1992 744 281
>1993 1177 619
>1994 690 368
>1995 599 495
>1996 5 3
>>It is evident the decreasing in 1994 and 1995.
>
The number of published heavy and light Ig's (I assume that is what
you meant by heavy and light) has been declining in the literature.
That might not mean that there are fewer sequences being sequenced
but that the journals are opting not to publish the sequence in its
entirety or at all, or the authors are not putting them in their
articles. For example, some workers might wish to submit their sequenes
to genbank and *not* publish them in their article(s). These sequences
will not be in our database.
As with the MHC proteins, the number of Ig may be declining due to
lack of interest (funding--not as many people working on it) or because
everything has been sequenced (ha!)....
I'll tell ya'll this--the number of *complete* Ig sequences has definitely
been declining. Many of the sequences we put in are CDRH3 fragments with
the variable region (and alas two other CDRs) lost at the back end of the
primer.
--George
