Wow! I have no idea what this is. Can anyone help? It's produced by
neutrophils and binds to a receptor. One place it binds is on primary
afferent nociceptors and sensitizes those neurons. Since I study
sensitization of nociceptors, I should find out what this is. An
antagonist at the receptor would be extra nice, but I won't hold my
breath :). It's produced by lipoxygenase, so maybe it's a prostaglandin?
Thanks...
Sandra
P.S., I'm not an immunologist, so go slow :)
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sandraw at U.Arizona.EDU
