Sandra L Wegert <sandraw at U.Arizona.EDU> wrote:
>Wow! I have no idea what this is. Can anyone help? It's produced by
>neutrophils and binds to a receptor. One place it binds is on primary
>afferent nociceptors and sensitizes those neurons. Since I study
>sensitization of nociceptors, I should find out what this is. An
>antagonist at the receptor would be extra nice, but I won't hold my
>breath :). It's produced by lipoxygenase, so maybe it's a prostaglandin?
It is part of the arachidonic acid cascade. HETE=hydrotetraenoic acid.
The enzyme from aa to 15-HETE is 15-lipoxygenase. 5,15-DiHETE arises
from the aa-5-lipoxygenase pathway. Prostaglandins arise from
cyclo-oxygenase pathways, as do thromboxanes. There's a nice chart on
pp. 250-251 of Jan Klein's Immunology.
Hope this helps.
George M. Carter
