Kim Dawe (kim.dawe at eu.pnu.com) wrote:
: Does any one know the precise mechanism of action of Con A when used to
: stimulate T-cells, why is there a requirement for APC's? Does ConA
: stimulate APC's to provide T-cell help or is there a direct interaction
: between the APC and T-cell.
: If anyone has any answers or knows a good paper thet will tell me all I
: would very much appreciate your help.
: Thanks
: Kim Dawe
I beleive ConA acts as a mitogen, and activates T cells non-specifically by
interaction with the T cell receptor. Therefore APC's are not needed to
elicit T cell proliferation. I would also be interested in a good paper
on this particular subject, if someone else responds.
by
pat
ptelmer at uoguelph.ca
