In article <319A58E2.43C3 at orgtx71.med.uth.tmc.edu> Jason Hebert,
hebertj at orgtx71.med.uth.tmc.edu writes:
>What your forgetting about, is the antibody response, the more
>closely related the histo-typing the more likely that the
>receipent will suffer acute rejection. However, in some
>animal studies with xenographs and completely unrelated
>histo-matching, have been quite succesful.
If I may chime in with the dogmatic theoretical immunology viewpoint.
Normal TcR recognition of MHC is via small changes in the "look" of MHC
with the foreign peptide inside. There may also be small conformational
changes in the MHC groove. Allo response is huge because the allo MHC
with any peptide looks different and you get apporx. 10% of the T cells
responding... So theoretically a very different xenograft should have
less of this type of rejection. However, you run into serious minor
histo Ags when using xenografts....
